While the speaker (Amber/Orange lights flashing) and TV is OFF. 

Press and hold the Accuvoice button on the ZVOX remote for 5 seconds, or until you see the amber/Orange and blue lights flash twice followed by a single amber/orange flashing light indicating the first step of learning a remote which is the volume up function.  

Hard press and hold the volume up button on your preferred remote until the amber/Orange light stops flashing.
Once you've finished learning the volume up function, the AV100 will start flashing a blue indicating the volume down button.

Follow the same steps for volume down until the blue flashing light turns into amber/Orange and blue flashing simultaneously indicating the 3rd step to learn, the mute button.
Go through the 3rd learn step with the mute button on your preferred remote 

Hard press and hold the mute button on your preferred remote until the amber/Orange and blue lights stops flashing. 

You will see alternating amber/Orange and blue lights indicating to learn the power function. Hard press the power button and go through the power learn steps and at the end no lights will flash on the display when done.
At the end you will be able to use your preferred remote to control the ZVOX system.